The Best Boutique Hotels to Book in St. Louis, Missouri

Hotel Saint Louis, Autograph Collection offers a spot of poolside relaxation after a day seeing the sights
Hotel Saint Louis, Autograph Collection offers a spot of poolside relaxation after a day seeing the sights | Courtesy of Hotel Saint Louis, Autograph Collection / Expedia

The second-largest city in Missouri is a bustling metropolis that spills into neighboring Illinois at its outer limits. With finishing touches such as themed color palettes and moon sculptures, these boutique hotels in St. Louis – bookable on Culture Trip – will prepare you for what the Gateway City has to offer.

Known for its arch towering over the banks of the Mississippi River, St. Louis was once considered an explorer’s gateway to the West. Nowadays, it’s a gateway to city exploration, from museums to parks and botanic gardens to sporting events and, of course, that famous frozen custard. These unique boutique hotels will allow you to immerse yourself in the St. Louis neighborhood of your choosing, whether you prefer a space travel vibe in Delmar Loop or a pastoral château in Wildwood.

1. Moonrise Hotel

Hotel

A stylish balcony with armchairs and dark wall art above the lobby of the Moonrise Hotel in St Louis
Courtesy of Moonrise Hotel / Expedia

A highlight of the Delmar Loop neighborhood, this St. Louis boutique hotel is known for its contemporary design with a nod to space-age styling. Suites are named after folks from the St. Louis Hall of Fame, including Josephine Baker, Tennessee Williams and Betty Grable. Bring your pet with you on vacation and check out the bright colors, funky decor and three on-site restaurants and bars. You’ll know you’re in the right place when you see the full moon on the roof. Moonrise is close to light rail, the university, restaurants, music venues and bars, although you may be inclined to just stay here and hang out on the rooftop patio or gaze at the illuminated lobby staircase.

2. Angad Arts Hotel

Hotel

A red and artsy bedroom at Angad Arts Hotel with a see-through chair and eyes painted on the cushions
Courtesy of Angad Arts Hotel / Expedia

Choose your room based on your mood: Feeling powerful? Go for red. Curious? Book a yellow suite. Each floor of the renovated hotel is a different color – in a way that is exciting and creative and not at all kitschy. Spacious suites include kitchenettes and room to work and play. Take a tour of the art exhibits from regional artists and the views of the Gateway Arch from the rooftop patio, as well as the surrounding Grand Center Arts District, which is home to museums, galleries and the iconic Sheldon Concert Hall.

3. The Cheshire

Hotel

A traditional and homely bedroom at The Cheshire
Courtesy of the Cheshire / Expedia

At one point in its history, this Tudor-style building was a burger restaurant. A renovation a decade ago turned it into a British-themed hotel in the upscale Clayton area. Enjoy the stained-glass windows in the lobby, the poolside terrace and the Fox and Hounds restaurant when you want that Old World feel. The 108 guest rooms, of course, have all the basic amenities that 21st century travelers want. The hotel is close to the zoo and Forest Park.

4. Magnolia Hotel St. Louis, A Tribute Portfolio Hotel

Chain Hotel

A white and modern hotel room at Magnolia Hotel St Louis
Courtesy of Magnolia Hotel St. Louis, A Tribute Portfolio Hotel / Expedia

Do you enjoy having chocolates left on your hotel pillow at night? The legend goes that actor Cary Grant started that practice here, at the Magnolia, which has been a hotel with different names since 1924. (These days, you may get cookies on turn-down instead.) The pet-friendly hotel has guest rooms updated with modern amenities, while the lobby retains its historic charm and is a destination for many folks staying downtown. As is the case with many hotels in historic buildings, room size may vary substantially, from expansive suites to cozy queens.

5. Hotel Indigo St. Louis – Downtown

Boutique Hotel, Chain Hotel

A stylish hotel room at Hotel Indigo St Louis – Downtown with black and white art on the back wall and windows overlooking the city
Courtesy of Hotel Indigo St. Louis – Downtown / Expedia

The exceptionally friendly and attentive staff make this 88-room hotel in downtown St. Louis a home-away-from-home kind of place. Some of the guest rooms may be small, but many have great views of the bustling city and feature in-room coffeemakers and desks if you need to get some work done. Check out the rooftop deck and views of the Gateway Arch, or borrow a bicycle from the front desk and explore the city on two wheels.

6. Seven Gables Inn

Independent Hotel, Inn

A stylish and bright hotel room at Seven Gables Inn with a blue armchair
Courtesy of Seven Gables Inn / Expedia

A small, 32-room-hotel in the upscale Clayton area, Seven Gables is popular for weddings and family gatherings when a group wants to be together, as well as for romantic getaways and those who want quiet with their R&R. The renovated 1926 inn has a restaurant, bar and courtyard, plus fuzzy robes for curling up in your room with. Heated toilet seats are an unexpected perk on cold St. Louis nights. Guest rooms in this historic building are spacious, and you’re welcome to bring your pet with you.

7. Hotel Saint Louis, Autograph Collection

Chain Hotel

A classy and tall hotel room at Hotel Saint Louis, Autograph Collection, with a grey colour scheme and a chandelier
Courtesy of Hotel Saint Louis, Autograph Collection / Expedia

If you like a suite set-up when you travel, this historic hotel has options for you. Of the 140 rooms in the hotel, 52 of them are suites. The hotel is within walking distance of much of downtown St. Louis’s charms, including Busch Stadium, where the Cardinals play baseball, and the Gateway Arch. Many rooms have views of the cityscape and nice architectural elements framing those views. Unwind at the on-site outdoor pool or spa.

8. The Wildwood Hotel

Boutique Hotel

A cream room at The Wildwood Hotel with two white double beds and wall-mounted paintings
Courtesy of the Wildwood Hotel / Expedia

The map says West St. Louis. The architecture says French countryside. This hotel, about 30 minutes west of downtown St. Louis, is popular with wedding parties as well as those who like to get outdoors, as it’s close to hiking and biking trails, as well as a winter ski resort. Room decor in this pet-friendly hotel fits the château theme and is more ornate than the sleek, modern design of many current hotels. Rooms are spacious, with seating areas as well as sleeping areas.

For more options, discover the best luxury hotels in St. Louis, or where to stay in St Louis. On a budget? Check out our guide to the best hotels in St Louis, Missouri, for every traveler, or if you’re looking for a more romantic stay, check out our guide to the most romantic hotels in St Louis, Missouri, bookable with Culture Trip. Bringing your furry friend? Discover these pet-friendly hotels in St Louis.

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