It started life as a smoggy industrial center but Steel City has been reinvented as a hip, modern metropolis. Enter by crossing one of its 446 (yup, count ‘em) bridges and you’ll discover a diverse patchwork of almost 100 neighborhoods, from the museum-dense Northside to hipster Lawrenceville or evergreen Downtown. A vibrant food scene, artsy culture and devoted local people make it an essential stop on any American road trip. Need a place to stay? Check out our guide to the best hotels in Pittsburgh.