Rurrenabeque
This small jungle town serves as the primary gateway for tours visiting the dense Amazon jungle of Madidi or the wildlife rich pampas region. Relaxed Rurrenabeque has plenty of hotels catering for a variety of budgets as well as a smattering of tourist friendly restaurants, bars and travel agents. Although it is only 250 miles (400 km) north of La Paz, the unpaved road requires a 16 hour journey which is notoriously tiring and treacherous. At less than 70BOB one way (US$10), the bus is okay for travelers on an exceptionally tight budget. However, a BOB490 (US$70) 35 minute flight with Amaszonas is well worth it if your budget will allow.

Quite Rurrenabeque street | © Jonathan Hood/Flickr