The Best Boutique Hotels in St. Louis, Missouri

Hotel Saint Louis, Autograph Collection offers a spot of poolside relaxation after a day seeing the sights
Hotel Saint Louis, Autograph Collection offers a spot of poolside relaxation after a day seeing the sights | Courtesy of Hotel Saint Louis, Autograph Collection / Expedia
Photo of Margaret Littman
29 June 2021

As Missouri’s second-largest city, St. Louis is a bustling metropolis that spills into neighboring Illinois at its outer limits. With finishing touches such as themed color palettes and moon sculptures, these boutique hotels – bookable on Culture Trip – will prepare you for what the Gateway City has to offer.

Known for its arch towering over the banks of the Mississippi River, St. Louis was once considered an explorer’s gateway to the West. Nowadays, it’s a gateway to city exploration, from museums to parks and botanic gardens to sporting events and, of course, that famous frozen custard. These unique boutique hotels will allow you to immerse yourself in the St. Louis neighborhood of your choosing, whether you prefer a space travel vibe in Delmar Loop or a pastoral château in Wildwood.

Moonrise Hotel

Hotel
4.7/5 (973 Reviews)
Moonrise Hotel_6f1c220b
Courtesy of Moonrise Hotel / Expedia
From $168 Per night per room

A highlight of the Delmar Loop neighborhood, this hotel is known for its contemporary design with a nod to space-age styling. Suites are named after folks from the St. Louis Hall of Fame, including Josephine Baker, Tennessee Williams and Betty Grable. Bring your pet with you on vacation and check out the bright colors, funky decor and three on-site restaurants and bars. You’ll know you’re in the right place when you see the full moon on the roof. Moonrise is close to light rail, the university, restaurants, music venues and bars, although you may be inclined to just stay here and hang out on the rooftop patio or gaze at the illuminated lobby staircase.

More info

Angad Arts Hotel

Hotel
4.7/5 (710 Reviews)
Angad Arts Hotel_7108464c
Courtesy of Angad Arts Hotel / Expedia
From $147 Per night per room

Choose your room based on your mood: Feeling powerful? Go for red. Curious? Book a yellow suite. Each floor of the renovated hotel is a different color – in a way that is exciting and creative and not at all kitschy. Spacious suites include kitchenettes and room to work and play. Take a tour of the art exhibits from regional artists and the views of the Gateway Arch from the rooftop patio, as well as the surrounding Grand Center Arts District, which is home to museums, galleries and the iconic Sheldon Concert Hall.

More info

The Cheshire

Hotel
4.2/5 (959 Reviews)
The Cheshire_f0ef7737
Courtesy of the Cheshire / Expedia
From $168 Per night per room

At one point in its history, this Tudor-style building was a burger restaurant. A renovation a decade ago turned it into a British-themed hotel in the upscale Clayton area. Enjoy the stained-glass windows in the lobby, the poolside terrace and the Fox and Hounds restaurant when you want that Old World feel. The 108 guest rooms, of course, have all the basic amenities that 21st century travelers want. The hotel is close to the zoo and Forest Park.

More info

Magnolia Hotel St. Louis, A Tribute Portfolio Hotel

Chain Hotel
4.3/5 (969 Reviews)
Magnolia Hotel St Louis, a Tribute Portfolio Hotel_9151aaef
Courtesy of Magnolia Hotel St. Louis, A Tribute Portfolio Hotel / Expedia
From $165 Per night per room

Do you enjoy having chocolates left on your hotel pillow at night? The legend goes that actor Cary Grant started that practice here, at the Magnolia, which has been a hotel with different names since 1924. (These days, you may get cookies on turn-down instead.) The pet-friendly hotel has guest rooms updated with modern amenities, while the lobby retains its historic charm and is a destination for many folks staying downtown. As is the case with many hotels in historic buildings, room size may vary substantially, from expansive suites to cozy queens.

More info

Why Book With Culture Trip?

  • Free cancellation

    In these uncertain times, cancel or change for free on select properties.

  • Price-match guarantee

    Find a better price on your booking and we’ll match it. Simple.

  • Unbiased & trustworthy

    Book from recommendations handpicked by travel experts.

  • Hotel Indigo St. Louis – Downtown

    Boutique Hotel, Chain Hotel
    4.4/5 (35 Reviews)
    Hotel Indigo St Louis – Downtown_978cb776
    Courtesy of Hotel Indigo St. Louis – Downtown / Expedia
    From $164 Per night per room

    The exceptionally friendly and attentive staff make this 88-room hotel in downtown St. Louis a home-away-from-home kind of place. Some of the guest rooms may be small, but many have great views of the bustling city and feature in-room coffeemakers and desks if you need to get some work done. Check out the rooftop deck and views of the Gateway Arch, or borrow a bicycle from the front desk and explore the city on two wheels.

    More info

    Seven Gables Inn

    Independent Hotel, Inn
    4.1/5 (528 Reviews)
    Seven Gables Inn_4afc83e7
    Courtesy of Seven Gables Inn / Expedia
    From $158 Per night per room

    A small, 32-room-hotel in the upscale Clayton area, Seven Gables is popular for weddings and family gatherings when a group wants to be together, as well as for romantic getaways and those who want quiet with their R&R. The renovated 1926 inn has a restaurant, bar and courtyard, plus fuzzy robes for curling up in your room with. Heated toilet seats are an unexpected perk on cold St. Louis nights. Guest rooms in this historic building are spacious, and you’re welcome to bring your pet with you.

    More info

    Hotel Saint Louis, Autograph Collection

    Chain Hotel
    4.6/5 (113 Reviews)
    Hotel Saint Louis, Autograph Collection_18e60796
    Courtesy of Hotel Saint Louis, Autograph Collection / Expedia
    From $230 Per night per room

    If you like a suite set-up when you travel, this historic hotel has options for you. Of the 140 rooms in the hotel, 52 of them are suites. The hotel is within walking distance of much of downtown St. Louis’s charms, including Busch Stadium, where the Cardinals play baseball, and the Gateway Arch. Many rooms have views of the cityscape and nice architectural elements framing those views. Unwind at the on-site outdoor pool or spa.

    More info

    The Wildwood Hotel

    Boutique Hotel
    4.4/5 (909 Reviews)
    The Wildwood Hotel_a11757b0
    Courtesy of the Wildwood Hotel / Expedia
    From $114 Per night per room

    The map says West St. Louis. The architecture says French countryside. This hotel, about 30 minutes west of downtown St. Louis, is popular with wedding parties as well as those who like to get outdoors, as it’s close to hiking and biking trails, as well as a winter ski resort. Room decor in this pet-friendly hotel fits the château theme and is more ornate than the sleek, modern design of many current hotels. Rooms are spacious, with seating areas as well as sleeping areas.

    More info
    These recommendations were updated on June 29, 2021 to keep your travel plans fresh.

    Cookies Policy

    We and our partners use cookies to better understand your needs, improve performance and provide you with personalised content and advertisements. To allow us to provide a better and more tailored experience please click "OK"